Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosomal degradation of N-Myc (and STAT) interactor.
Identifieur interne : 001244 ( Main/Exploration ); précédent : 001243; suivant : 001245Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosomal degradation of N-Myc (and STAT) interactor.
Auteurs : Weijia Cheng [République populaire de Chine] ; Shiyou Chen ; Ruiling Li ; Yu Chen ; Min Wang ; Deyin GuoSource :
- Virologica Sinica [ 1995-820X ] ; 2015.
Descripteurs français
- KwdFr :
- Banque de gènes, Cartographie d'interactions entre protéines, Humains, Interactions hôte-pathogène, Liaison aux protéines, Protéines et peptides de signalisation intracellulaire (métabolisme), Protéines virales (métabolisme), Protéolyse, Techniques de double hybride, Ubiquitine (métabolisme), Virus du SRAS (physiologie).
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Intracellular Signaling Peptides and Proteins, Ubiquitin, Viral Proteins.
- physiology : SARS Virus.
- Gene Library, Host-Pathogen Interactions, Humans, Protein Binding, Protein Interaction Mapping, Proteolysis, Two-Hybrid System Techniques.
Abstract
Severe acute respiratory syndrome coronavirus (SARS-CoV) encodes eight accessory proteins, the functions of which are not yet fully understood. SARS-CoV protein 6 (P6) is one of the previously studied accessory proteins that have been documented to enhance viral replication and suppress host interferon (IFN) signaling pathways. Through yeast two-hybrid screening, we identified eight potential cellular P6-interacting proteins from a human spleen cDNA library. For further investigation, we targeted the IFN signaling pathway-mediating protein, N-Myc (and STAT) interactor (Nmi). Its interaction with P6 was confirmed within cells. The results showed that P6 can promote the ubiquitin-dependent proteosomal degradation of Nmi. This study revealed a new mechanism of SARS-CoV P6 in limiting the IFN signaling to promote SARS-CoV survival in host cells.
DOI: 10.1007/s12250-015-3581-8
PubMed: 25907116
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000E27
- to stream PubMed, to step Curation: 000E27
- to stream PubMed, to step Checkpoint: 000D62
- to stream Ncbi, to step Merge: 002A65
- to stream Ncbi, to step Curation: 002A65
- to stream Ncbi, to step Checkpoint: 002A65
- to stream Main, to step Merge: 001246
- to stream Main, to step Curation: 001244
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosomal degradation of N-Myc (and STAT) interactor.</title><author><name sortKey="Cheng, Weijia" sort="Cheng, Weijia" uniqKey="Cheng W" first="Weijia" last="Cheng">Weijia Cheng</name><affiliation wicri:level="4"><nlm:affiliation>School of Basic Medical Sciences, Wuhan University, Wuhan, 430072, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Basic Medical Sciences, Wuhan University, Wuhan, 430072</wicri:regionArea><orgName type="university">Université de Wuhan</orgName><placeName><settlement type="city">Wuhan</settlement><region type="province">Hubei</region></placeName></affiliation></author><author><name sortKey="Chen, Shiyou" sort="Chen, Shiyou" uniqKey="Chen S" first="Shiyou" last="Chen">Shiyou Chen</name></author><author><name sortKey="Li, Ruiling" sort="Li, Ruiling" uniqKey="Li R" first="Ruiling" last="Li">Ruiling Li</name></author><author><name sortKey="Chen, Yu" sort="Chen, Yu" uniqKey="Chen Y" first="Yu" last="Chen">Yu Chen</name></author><author><name sortKey="Wang, Min" sort="Wang, Min" uniqKey="Wang M" first="Min" last="Wang">Min Wang</name></author><author><name sortKey="Guo, Deyin" sort="Guo, Deyin" uniqKey="Guo D" first="Deyin" last="Guo">Deyin Guo</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25907116</idno><idno type="pmid">25907116</idno><idno type="doi">10.1007/s12250-015-3581-8</idno><idno type="wicri:Area/PubMed/Corpus">000E27</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E27</idno><idno type="wicri:Area/PubMed/Curation">000E27</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000E27</idno><idno type="wicri:Area/PubMed/Checkpoint">000D62</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D62</idno><idno type="wicri:Area/Ncbi/Merge">002A65</idno><idno type="wicri:Area/Ncbi/Curation">002A65</idno><idno type="wicri:Area/Ncbi/Checkpoint">002A65</idno><idno type="wicri:Area/Main/Merge">001246</idno><idno type="wicri:Area/Main/Curation">001244</idno><idno type="wicri:Area/Main/Exploration">001244</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosomal degradation of N-Myc (and STAT) interactor.</title><author><name sortKey="Cheng, Weijia" sort="Cheng, Weijia" uniqKey="Cheng W" first="Weijia" last="Cheng">Weijia Cheng</name><affiliation wicri:level="4"><nlm:affiliation>School of Basic Medical Sciences, Wuhan University, Wuhan, 430072, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Basic Medical Sciences, Wuhan University, Wuhan, 430072</wicri:regionArea><orgName type="university">Université de Wuhan</orgName><placeName><settlement type="city">Wuhan</settlement><region type="province">Hubei</region></placeName></affiliation></author><author><name sortKey="Chen, Shiyou" sort="Chen, Shiyou" uniqKey="Chen S" first="Shiyou" last="Chen">Shiyou Chen</name></author><author><name sortKey="Li, Ruiling" sort="Li, Ruiling" uniqKey="Li R" first="Ruiling" last="Li">Ruiling Li</name></author><author><name sortKey="Chen, Yu" sort="Chen, Yu" uniqKey="Chen Y" first="Yu" last="Chen">Yu Chen</name></author><author><name sortKey="Wang, Min" sort="Wang, Min" uniqKey="Wang M" first="Min" last="Wang">Min Wang</name></author><author><name sortKey="Guo, Deyin" sort="Guo, Deyin" uniqKey="Guo D" first="Deyin" last="Guo">Deyin Guo</name></author></analytic><series><title level="j">Virologica Sinica</title><idno type="eISSN">1995-820X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Gene Library</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Intracellular Signaling Peptides and Proteins (metabolism)</term><term>Protein Binding</term><term>Protein Interaction Mapping</term><term>Proteolysis</term><term>SARS Virus (physiology)</term><term>Two-Hybrid System Techniques</term><term>Ubiquitin (metabolism)</term><term>Viral Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Banque de gènes</term><term>Cartographie d'interactions entre protéines</term><term>Humains</term><term>Interactions hôte-pathogène</term><term>Liaison aux protéines</term><term>Protéines et peptides de signalisation intracellulaire (métabolisme)</term><term>Protéines virales (métabolisme)</term><term>Protéolyse</term><term>Techniques de double hybride</term><term>Ubiquitine (métabolisme)</term><term>Virus du SRAS (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Intracellular Signaling Peptides and Proteins</term><term>Ubiquitin</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines et peptides de signalisation intracellulaire</term><term>Protéines virales</term><term>Ubiquitine</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Gene Library</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Protein Binding</term><term>Protein Interaction Mapping</term><term>Proteolysis</term><term>Two-Hybrid System Techniques</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Banque de gènes</term><term>Cartographie d'interactions entre protéines</term><term>Humains</term><term>Interactions hôte-pathogène</term><term>Liaison aux protéines</term><term>Protéolyse</term><term>Techniques de double hybride</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome coronavirus (SARS-CoV) encodes eight accessory proteins, the functions of which are not yet fully understood. SARS-CoV protein 6 (P6) is one of the previously studied accessory proteins that have been documented to enhance viral replication and suppress host interferon (IFN) signaling pathways. Through yeast two-hybrid screening, we identified eight potential cellular P6-interacting proteins from a human spleen cDNA library. For further investigation, we targeted the IFN signaling pathway-mediating protein, N-Myc (and STAT) interactor (Nmi). Its interaction with P6 was confirmed within cells. The results showed that P6 can promote the ubiquitin-dependent proteosomal degradation of Nmi. This study revealed a new mechanism of SARS-CoV P6 in limiting the IFN signaling to promote SARS-CoV survival in host cells. </div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Hubei</li></region><settlement><li>Wuhan</li></settlement><orgName><li>Université de Wuhan</li></orgName></list><tree><noCountry><name sortKey="Chen, Shiyou" sort="Chen, Shiyou" uniqKey="Chen S" first="Shiyou" last="Chen">Shiyou Chen</name><name sortKey="Chen, Yu" sort="Chen, Yu" uniqKey="Chen Y" first="Yu" last="Chen">Yu Chen</name><name sortKey="Guo, Deyin" sort="Guo, Deyin" uniqKey="Guo D" first="Deyin" last="Guo">Deyin Guo</name><name sortKey="Li, Ruiling" sort="Li, Ruiling" uniqKey="Li R" first="Ruiling" last="Li">Ruiling Li</name><name sortKey="Wang, Min" sort="Wang, Min" uniqKey="Wang M" first="Min" last="Wang">Min Wang</name></noCountry><country name="République populaire de Chine"><region name="Hubei"><name sortKey="Cheng, Weijia" sort="Cheng, Weijia" uniqKey="Cheng W" first="Weijia" last="Cheng">Weijia Cheng</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001244 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001244 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:25907116
|texte= Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosomal degradation of N-Myc (and STAT) interactor.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25907116" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |